Drug interactions
Hydrochlorothiazide-lisinopril + Mycophenolate
Severity: Minor
Hydrochlorothiazide-lisinopril and Mycophenolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides may compete with the inactive mycophenolic acid glucuronide for renal tubular secretion and could raise its levels. The clinical consequence is uncertain, and the evidence is limited.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular secretion via organic anion transporters.
What to do
No routine dose change is needed; monitor for mycophenolate adverse effects such as cytopenias and gastrointestinal toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Mycophenolate?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides may compete with the inactive mycophenolic acid glucuronide for renal tubular secretion and could raise its levels. The clinical consequence is uncertain, and the evidence is limited.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Mycophenolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for mycophenolate adverse effects such as cytopenias and gastrointestinal toxicity.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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