Drug interactions
Hydrochlorothiazide-lisinopril + Nafcillin
Severity: Minor
Hydrochlorothiazide-lisinopril and Nafcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are organic acids that undergo tubular secretion, so competition could modestly reduce renal clearance of each. Nafcillin is mainly cleared by the liver, and the clinical significance is likely small. Nafcillin may also cause hypokalemia at high doses, adding to thiazide effects.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular secretion through organic anion transport; nafcillin-related potassium loss may add to thiazide effects.
What to do
No dose adjustment is usually required; monitor serum potassium during high-dose or prolonged nafcillin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-lisinopril and Nafcillin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Nafcillin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are organic acids that undergo tubular secretion, so competition could modestly reduce renal clearance of each. Nafcillin is mainly cleared by the liver, and the clinical significance is likely small. Nafcillin may also cause hypokalemia at high doses, adding to thiazide effects.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Nafcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor serum potassium during high-dose or prolonged nafcillin therapy.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
