Drug interactions
Hydrochlorothiazide-lisinopril + Nitroglycerin rectal
Severity: Moderate
Hydrochlorothiazide-lisinopril and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin causes vasodilation and, with a diuretic and ACE inhibitor, may cause additive blood pressure lowering. Patients can experience dizziness, orthostatic hypotension or syncope.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and hypotensive effects, with diuretic-induced volume reduction.
What to do
Monitor blood pressure, including standing, when starting nitroglycerin, and advise patients to rise slowly. Reduce antihypertensive doses if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin causes vasodilation and, with a diuretic and ACE inhibitor, may cause additive blood pressure lowering. Patients can experience dizziness, orthostatic hypotension or syncope.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing, when starting nitroglycerin, and advise patients to rise slowly. Reduce antihypertensive doses if hypotension develops.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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