Drug interactions
Hydrochlorothiazide-lisinopril + Norepinephrine
Severity: Moderate
Hydrochlorothiazide-lisinopril and Norepinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norepinephrine is a potent vasopressor, so it will oppose the antihypertensive action of the combination. Its beta effects may slightly lower potassium, adding to thiazide-related hypokalemia, which matters for arrhythmia risk in critically ill patients.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic opposition of vasopressor and antihypertensive effects, plus minor beta-mediated potassium shift added to thiazide potassium loss.
What to do
Titrate norepinephrine to hemodynamic targets and monitor serum potassium and ECG in intensive care settings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Norepinephrine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Norepinephrine is a potent vasopressor, so it will oppose the antihypertensive action of the combination. Its beta effects may slightly lower potassium, adding to thiazide-related hypokalemia, which matters for arrhythmia risk in critically ill patients.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Norepinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate norepinephrine to hemodynamic targets and monitor serum potassium and ECG in intensive care settings.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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