Drug interactions
Hydrochlorothiazide-lisinopril + Olmesartan
Severity: Major
Hydrochlorothiazide-lisinopril and Olmesartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding an ARB to an ACE inhibitor produces dual renin-angiotensin system blockade, raising the risk of hypotension, hyperkalemia, and acute kidney injury without proven additional benefit.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Olmesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Olmesartan belongs to Cardiovascular.
Why it happens
Additive blockade of the renin-angiotensin-aldosterone system reduces aldosterone-mediated potassium excretion and efferent arteriolar tone.
What to do
Avoid the combination of an ACE inhibitor with an ARB where possible. If it is used, monitor potassium, creatinine, and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Olmesartan?
MediHelp rates the interaction as major. Hydrochlorothiazide-lisinopril and Olmesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Adding an ARB to an ACE inhibitor produces dual renin-angiotensin system blockade, raising the risk of hypotension, hyperkalemia, and acute kidney injury without proven additional benefit.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Olmesartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination of an ACE inhibitor with an ARB where possible. If it is used, monitor potassium, creatinine, and blood pressure closely.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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