Drug interactions
Hydrochlorothiazide-lisinopril + Olodaterol inhaled
Severity: Moderate
Hydrochlorothiazide-lisinopril and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics and beta-2 agonists can each lower serum potassium. Together they may produce additive hypokalemia, which can predispose to arrhythmias, especially in patients with heart disease or hypoxia. The effect is mainly relevant at higher beta-agonist doses.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia: thiazide-induced renal potassium loss plus beta-2 agonist-driven intracellular potassium shift.
What to do
Check serum potassium and magnesium at baseline and periodically in patients on this combination, particularly those with cardiac disease. Replace potassium if low; the ACE inhibitor component may partly offset the loss.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics and beta-2 agonists can each lower serum potassium. Together they may produce additive hypokalemia, which can predispose to arrhythmias, especially in patients with heart disease or hypoxia. The effect is mainly relevant at higher beta-agonist doses.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium at baseline and periodically in patients on this combination, particularly those with cardiac disease. Replace potassium if low; the ACE inhibitor component may partly offset the loss.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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