Drug interactions
Hydrochlorothiazide-lisinopril + Parecoxib
Severity: Moderate
Hydrochlorothiazide-lisinopril and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as parecoxib (via its active metabolite valdecoxib) can blunt the antihypertensive effect of ACE inhibitors and thiazides. Combined with an ACE inhibitor and diuretic, they raise the risk of acute kidney injury, particularly in volume-depleted or elderly patients, and can cause hyperkalemia.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium and fluid retention and reduces glomerular perfusion, which counteracts the drugs' effects and adds to renal hemodynamic stress.
What to do
Keep parecoxib to the shortest effective course with adequate hydration. Monitor blood pressure, serum creatinine and potassium, especially in the first weeks and in older or dehydrated patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Parecoxib?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as parecoxib (via its active metabolite valdecoxib) can blunt the antihypertensive effect of ACE inhibitors and thiazides. Combined with an ACE inhibitor and diuretic, they raise the risk of acute kidney injury, particularly in volume-depleted or elderly patients, and can cause hyperkalemia.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep parecoxib to the shortest effective course with adequate hydration. Monitor blood pressure, serum creatinine and potassium, especially in the first weeks and in older or dehydrated patients.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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