Drug interactions
Hydrochlorothiazide-lisinopril + Penbutolol
Severity: Minor
Hydrochlorothiazide-lisinopril and Penbutolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penbutolol is a beta-blocker that lowers blood pressure, and combining it with a thiazide and ACE inhibitor gives additive hypotension and possible bradycardia. Beta-blockade has only a minor effect on potassium, so any potassium interaction is of limited importance. Thiazides can also modestly impair glucose tolerance and mask the warning signs of hypoglycemia in diabetic patients on beta-blockers.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Penbutolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic blood pressure lowering through different pathways; beta-blockade slightly impairs cellular potassium uptake.
What to do
Monitor blood pressure and heart rate when starting or adjusting doses. Check potassium periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Penbutolol?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Penbutolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Penbutolol is a beta-blocker that lowers blood pressure, and combining it with a thiazide and ACE inhibitor gives additive hypotension and possible bradycardia. Beta-blockade has only a minor effect on potassium, so any potassium interaction is of limited importance. Thiazides can also modestly impair glucose tolerance and mask the warning signs of hypoglycemia in diabetic patients on beta-blockers.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Penbutolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting doses. Check potassium periodically.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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