Drug interactions
Hydrochlorothiazide-lisinopril + Penicillin g aqueous
Severity: Minor
Hydrochlorothiazide-lisinopril and Penicillin g aqueous: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides and penicillins are both secreted by renal organic anion transport in the proximal tubule. Competition can reduce penicillin clearance and raise penicillin levels. The effect is usually modest, but it matters at high penicillin G doses or in renal impairment, where neurotoxicity and seizures can occur.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Penicillin g aqueous have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular secretion through organic anion transporters.
What to do
No routine adjustment is needed. Monitor renal function and watch for neurotoxicity when high-dose penicillin G is used in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Penicillin g aqueous?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Penicillin g aqueous have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides and penicillins are both secreted by renal organic anion transport in the proximal tubule. Competition can reduce penicillin clearance and raise penicillin levels. The effect is usually modest, but it matters at high penicillin G doses or in renal impairment, where neurotoxicity and seizures can occur.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Penicillin g aqueous?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor renal function and watch for neurotoxicity when high-dose penicillin G is used in renal impairment.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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