Drug interactions
Hydrochlorothiazide-lisinopril + Pindolol
Severity: Minor
Hydrochlorothiazide-lisinopril and Pindolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pindolol, a beta-blocker with intrinsic sympathomimetic activity, adds to the blood pressure lowering of a thiazide and ACE inhibitor and may cause bradycardia or hypotension. Its effect on potassium is small and not clinically important. Thiazides may modestly worsen glucose control.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Pindolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antihypertensive effects through different mechanisms; minimal beta-blocker effect on potassium distribution.
What to do
Monitor blood pressure and heart rate after initiation or dose change. Check potassium and glucose periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Pindolol?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Pindolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pindolol, a beta-blocker with intrinsic sympathomimetic activity, adds to the blood pressure lowering of a thiazide and ACE inhibitor and may cause bradycardia or hypotension. Its effect on potassium is small and not clinically important. Thiazides may modestly worsen glucose control.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Pindolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate after initiation or dose change. Check potassium and glucose periodically.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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