Drug interactions
Hydrochlorothiazide-lisinopril + Reishi
Severity: Minor
Hydrochlorothiazide-lisinopril and Reishi: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reishi mushroom has been reported to have blood pressure lowering properties. Taken with a thiazide and ACE inhibitor combination, it could add to the antihypertensive effect and occasionally cause excessive hypotension.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Reishi have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive hypotensive effect; the mechanism is not firmly established.
What to do
Monitor blood pressure if the patient starts or stops reishi products, and reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Reishi?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Reishi have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reishi mushroom has been reported to have blood pressure lowering properties. Taken with a thiazide and ACE inhibitor combination, it could add to the antihypertensive effect and occasionally cause excessive hypotension.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Reishi?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if the patient starts or stops reishi products, and reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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