Drug interactions
Hydrochlorothiazide-lisinopril + Salicylates
Severity: Moderate
Hydrochlorothiazide-lisinopril and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates can have NSAID-like effects on the kidney, reducing the antihypertensive effect of ACE inhibitors and thiazides. With this combination the risk of renal impairment and hyperkalemia rises, particularly with high doses or volume depletion.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and promotes sodium retention.
What to do
Use the lowest effective salicylate dose and ensure adequate hydration. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Salicylates?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates can have NSAID-like effects on the kidney, reducing the antihypertensive effect of ACE inhibitors and thiazides. With this combination the risk of renal impairment and hyperkalemia rises, particularly with high doses or volume depletion.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective salicylate dose and ensure adequate hydration. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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