Drug interactions
Hydrochlorothiazide-lisinopril + Salsalate
Severity: Moderate
Hydrochlorothiazide-lisinopril and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate with NSAID-like properties that can weaken the blood pressure response to ACE inhibitors and thiazides. It adds to the risk of renal impairment and hyperkalemia in volume-depleted, elderly or renally impaired patients.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced renal prostaglandin synthesis causes sodium retention and decreased renal perfusion.
What to do
Monitor blood pressure, serum creatinine and potassium, especially at initiation and in at-risk patients. Use the lowest effective salsalate dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Salsalate?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate with NSAID-like properties that can weaken the blood pressure response to ACE inhibitors and thiazides. It adds to the risk of renal impairment and hyperkalemia in volume-depleted, elderly or renally impaired patients.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, especially at initiation and in at-risk patients. Use the lowest effective salsalate dose for the shortest time.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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