Drug interactions
Hydrochlorothiazide-lisinopril + Shark cartilage
Severity: Minor
Hydrochlorothiazide-lisinopril and Shark cartilage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Shark cartilage contains calcium and has been associated with hypercalcemia in some patients. Thiazides reduce urinary calcium excretion, so the two together could theoretically raise serum calcium.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Shark cartilage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide-reduced renal calcium excretion combined with calcium load from the supplement; the evidence is theoretical.
What to do
Check serum calcium if shark cartilage is used long term with the thiazide. Advise patients to report symptoms of hypercalcemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Shark cartilage?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Shark cartilage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Shark cartilage contains calcium and has been associated with hypercalcemia in some patients. Thiazides reduce urinary calcium excretion, so the two together could theoretically raise serum calcium.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Shark cartilage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum calcium if shark cartilage is used long term with the thiazide. Advise patients to report symptoms of hypercalcemia.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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