Drug interactions
Hydrochlorothiazide-lisinopril + Shepherd's purse
Severity: Minor
Hydrochlorothiazide-lisinopril and Shepherd's purse: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Shepherd's purse has traditionally been reported to affect blood pressure, and it may therefore alter the blood pressure control achieved with an antihypertensive regimen. The evidence is theoretical and the direction of the effect is not well defined.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Shepherd's purse have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Unestablished; possible direct effects of herbal constituents on vascular tone.
What to do
Advise patients to avoid shepherd's purse supplements, or check blood pressure regularly if they are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Shepherd's purse?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Shepherd's purse have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Shepherd's purse has traditionally been reported to affect blood pressure, and it may therefore alter the blood pressure control achieved with an antihypertensive regimen. The evidence is theoretical and the direction of the effect is not well defined.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Shepherd's purse?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid shepherd's purse supplements, or check blood pressure regularly if they are used.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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