Drug interactions
Hydrochlorothiazide-lisinopril + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Major
Hydrochlorothiazide-lisinopril and Sodium sulfate / ?magnesium sulfate / potassium chloride: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osmotic bowel preparations can cause fluid loss and electrolyte shifts. Together with a diuretic and ACE inhibitor, they raise the risk of dehydration, hyponatremia, arrhythmias, seizures and acute kidney injury.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Sodium sulfate / ?magnesium sulfate / potassium chloride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive fluid and electrolyte depletion from diuresis and bowel preparation, with reduced renal perfusion under ACE inhibition.
What to do
Consider withholding the diuretic and ACE inhibitor on the day of preparation and ensure adequate hydration. Check electrolytes and creatinine beforehand in high-risk patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as major. Hydrochlorothiazide-lisinopril and Sodium sulfate / ?magnesium sulfate / potassium chloride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Osmotic bowel preparations can cause fluid loss and electrolyte shifts. Together with a diuretic and ACE inhibitor, they raise the risk of dehydration, hyponatremia, arrhythmias, seizures and acute kidney injury.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider withholding the diuretic and ACE inhibitor on the day of preparation and ensure adequate hydration. Check electrolytes and creatinine beforehand in high-risk patients.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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