Drug interactions
Hydrochlorothiazide-lisinopril + Temocillin
Severity: Minor
Hydrochlorothiazide-lisinopril and Temocillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides and penicillins compete for renal tubular secretion, which may modestly delay temocillin elimination. Clinical consequences are usually small except in renal impairment.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular secretion via organic anion transporters.
What to do
No routine adjustment is needed. Review temocillin dosing in patients with reduced renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Temocillin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides and penicillins compete for renal tubular secretion, which may modestly delay temocillin elimination. Clinical consequences are usually small except in renal impairment.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Temocillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Review temocillin dosing in patients with reduced renal function.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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