Drug interactions
Hydrochlorothiazide-lisinopril + Triamcinolone acetonide injectable
Severity: Minor
Hydrochlorothiazide-lisinopril and Triamcinolone acetonide injectable: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids have some mineralocorticoid activity and promote potassium loss, which adds to thiazide-induced hypokalemia. Triamcinolone has little mineralocorticoid effect, so the risk is modest, but fluid retention may also blunt blood pressure control. The ACE inhibitor partly offsets potassium loss.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Triamcinolone acetonide injectable have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive renal potassium wasting; corticosteroid sodium retention may counteract the antihypertensive and diuretic effect.
What to do
Check serum potassium and blood pressure if repeated or high-dose corticosteroid injections are given, and replace potassium as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Triamcinolone acetonide injectable?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Triamcinolone acetonide injectable have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids have some mineralocorticoid activity and promote potassium loss, which adds to thiazide-induced hypokalemia. Triamcinolone has little mineralocorticoid effect, so the risk is modest, but fluid retention may also blunt blood pressure control. The ACE inhibitor partly offsets potassium loss.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Triamcinolone acetonide injectable?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and blood pressure if repeated or high-dose corticosteroid injections are given, and replace potassium as needed.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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