Drug interactions
Hydrochlorothiazide-lisinopril + Trilostane
Severity: Moderate
Hydrochlorothiazide-lisinopril and Trilostane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilostane inhibits adrenal steroid synthesis, including aldosterone, which reduces potassium excretion. With an ACE inhibitor it can cause hyperkalemia, and added to a thiazide it may enhance hyponatremia and hypotension.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Trilostane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of 3-beta-hydroxysteroid dehydrogenase lowers aldosterone, adding to ACE inhibitor-induced potassium retention and sodium loss.
What to do
Monitor serum potassium, sodium and blood pressure when the combination is used, and adjust therapy if hyperkalemia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-lisinopril and Trilostane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Trilostane?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Trilostane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilostane inhibits adrenal steroid synthesis, including aldosterone, which reduces potassium excretion. With an ACE inhibitor it can cause hyperkalemia, and added to a thiazide it may enhance hyponatremia and hypotension.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Trilostane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, sodium and blood pressure when the combination is used, and adjust therapy if hyperkalemia or hypotension develops.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
