Drug interactions
Hydrochlorothiazide-lisinopril + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Hydrochlorothiazide-lisinopril and Vilanterol / fluticasone furoate inhaled: moderate interaction.
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For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a beta-agonist, can lower serum potassium and may worsen hypokalemia and ECG changes caused by hydrochlorothiazide. The risk is greater at higher than recommended doses.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 agonism shifts potassium into cells, adding to thiazide-induced urinary potassium loss.
What to do
Use the recommended dose only and monitor potassium, especially in patients with other risk factors for hypokalemia. Lisinopril may partly offset potassium loss.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a beta-agonist, can lower serum potassium and may worsen hypokalemia and ECG changes caused by hydrochlorothiazide. The risk is greater at higher than recommended doses.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the recommended dose only and monitor potassium, especially in patients with other risk factors for hypokalemia. Lisinopril may partly offset potassium loss.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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