Drug interactions
Hydrochlorothiazide-lisinopril + Xipamide
Severity: Major
Hydrochlorothiazide-lisinopril and Xipamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic, so adding it to hydrochlorothiazide duplicates therapy. The result is excessive diuresis with hypotension, hyponatremia, hypokalemia and renal impairment, which is increased further with the ACE inhibitor.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Xipamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive inhibition of sodium chloride reabsorption in the distal tubule from two thiazide-type diuretics.
What to do
Avoid combining two thiazide-type diuretics. If sequential nephron blockade is intended, use a different class and monitor electrolytes and creatinine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Xipamide?
MediHelp rates the interaction as major. Hydrochlorothiazide-lisinopril and Xipamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Xipamide is a thiazide-like diuretic, so adding it to hydrochlorothiazide duplicates therapy. The result is excessive diuresis with hypotension, hyponatremia, hypokalemia and renal impairment, which is increased further with the ACE inhibitor.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Xipamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazide-type diuretics. If sequential nephron blockade is intended, use a different class and monitor electrolytes and creatinine.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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