Drug interactions
Hydrochlorothiazide-losartan + Insulin degludec
Severity: Moderate
Hydrochlorothiazide-losartan and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and impair glycemic control in diabetic patients, which may reduce the effect of insulin. Losartan may slightly improve insulin sensitivity, so the net effect varies.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Insulin degludec belongs to Endocrine.
Why it happens
Thiazide-induced hypokalemia and reduced insulin secretion and sensitivity oppose insulin action.
What to do
Monitor blood glucose and potassium after starting or changing the thiazide. Increase the insulin dose if hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Insulin degludec?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can raise blood glucose and impair glycemic control in diabetic patients, which may reduce the effect of insulin. Losartan may slightly improve insulin sensitivity, so the net effect varies.
How serious is the interaction between Hydrochlorothiazide-losartan and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium after starting or changing the thiazide. Increase the insulin dose if hyperglycemia develops.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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