Drug interactions
Hydrochlorothiazide-losartan + Insulin glulisine
Severity: Moderate
Hydrochlorothiazide-losartan and Insulin glulisine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan may improve insulin sensitivity and can increase the glucose-lowering effect of insulin, raising the chance of hypoglycemia. The hydrochlorothiazide component may work in the opposite direction by worsening glucose tolerance. Net glycemic effects can therefore vary between patients.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Insulin glulisine belongs to Endocrine.
Why it happens
Angiotensin receptor blockade may enhance insulin sensitivity, while thiazides can impair glucose tolerance through potassium depletion and reduced insulin secretion.
What to do
Monitor blood glucose more frequently when starting, stopping or changing the dose of the combination. Adjust the insulin dose according to glucose readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Insulin glulisine
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Insulin glulisine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Losartan may improve insulin sensitivity and can increase the glucose-lowering effect of insulin, raising the chance of hypoglycemia. The hydrochlorothiazide component may work in the opposite direction by worsening glucose tolerance. Net glycemic effects can therefore vary between patients.
How serious is the interaction between Hydrochlorothiazide-losartan and Insulin glulisine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting, stopping or changing the dose of the combination. Adjust the insulin dose according to glucose readings.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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