Drug interactions
Hydrochlorothiazide-losartan + Ivosidenib
Severity: Moderate
Hydrochlorothiazide-losartan and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may induce CYP2C9, which could lower exposure to losartan and its active metabolite. Blood pressure control may become less effective.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Ivosidenib belongs to Oncology.
Why it happens
Enzyme induction of CYP3A4 and CYP2C9 by ivosidenib increases losartan clearance.
What to do
Monitor blood pressure after starting or stopping ivosidenib and increase losartan or add another antihypertensive if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Ivosidenib?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may induce CYP2C9, which could lower exposure to losartan and its active metabolite. Blood pressure control may become less effective.
How serious is the interaction between Hydrochlorothiazide-losartan and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping ivosidenib and increase losartan or add another antihypertensive if control is lost.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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