Drug interactions
Hydrochlorothiazide-losartan + Larotrectinib
Severity: Minor
Hydrochlorothiazide-losartan and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with weak inhibitory potential, and any effect on losartan exposure is expected to be small. Losartan activation relies chiefly on CYP2C9, so clinical significance is doubtful.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition altering losartan metabolism.
What to do
No adjustment needed; monitor blood pressure routinely.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Larotrectinib?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with weak inhibitory potential, and any effect on losartan exposure is expected to be small. Losartan activation relies chiefly on CYP2C9, so clinical significance is doubtful.
How serious is the interaction between Hydrochlorothiazide-losartan and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; monitor blood pressure routinely.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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