Drug interactions
Hydrochlorothiazide-losartan + Lorlatinib
Severity: Minor
Hydrochlorothiazide-losartan and Lorlatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4 and may lower losartan exposure. Because losartan is also metabolized by CYP2C9, the effect on antihypertensive response is probably small.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Lorlatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induction of CYP3A4 may increase losartan metabolism.
What to do
No routine dose change is needed. Monitor blood pressure during lorlatinib therapy and adjust antihypertensive dosing if control declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Lorlatinib?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Lorlatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorlatinib induces CYP3A4 and may lower losartan exposure. Because losartan is also metabolized by CYP2C9, the effect on antihypertensive response is probably small.
How serious is the interaction between Hydrochlorothiazide-losartan and Lorlatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor blood pressure during lorlatinib therapy and adjust antihypertensive dosing if control declines.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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