Drug interactions
Hydrochlorothiazide-losartan + Magnesium citrate
Severity: Minor
Hydrochlorothiazide-losartan and Magnesium citrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide increases urinary magnesium loss and may lead to hypomagnesemia with long-term use. Magnesium citrate given as a supplement may offset this, whereas as a laxative it provides only transient magnesium.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Magnesium citrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Magnesium citrate belongs to Gastrointestinal Tract.
Why it happens
Thiazides increase renal magnesium excretion, lowering serum magnesium.
What to do
Monitor serum magnesium in long-term thiazide users and supplement if low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Magnesium citrate
- Ciprofloxacin + Magnesium citrate Major
- Baloxavir marboxil + Magnesium citrate Moderate
- Bictegravir + Magnesium citrate Moderate
- Cabotegravir + Magnesium citrate Moderate
- Cholecalciferol + Magnesium citrate Moderate
- Deferiprone + Magnesium citrate Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Magnesium citrate?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Magnesium citrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide increases urinary magnesium loss and may lead to hypomagnesemia with long-term use. Magnesium citrate given as a supplement may offset this, whereas as a laxative it provides only transient magnesium.
How serious is the interaction between Hydrochlorothiazide-losartan and Magnesium citrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium in long-term thiazide users and supplement if low.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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