Drug interactions
Hydrochlorothiazide-losartan + Nateglinide
Severity: Minor
Hydrochlorothiazide-losartan and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide is metabolised partly by CYP2C9 and may weakly inhibit it in vitro, which could theoretically reduce conversion of losartan to its active metabolite. No clinically meaningful effect has been established.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Nateglinide belongs to Endocrine.
Why it happens
Theoretical CYP2C9 competition affecting losartan activation to E-3174; clinical significance not established.
What to do
No dose change is needed; monitor blood pressure if therapy is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Nateglinide?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nateglinide is metabolised partly by CYP2C9 and may weakly inhibit it in vitro, which could theoretically reduce conversion of losartan to its active metabolite. No clinically meaningful effect has been established.
How serious is the interaction between Hydrochlorothiazide-losartan and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor blood pressure if therapy is started or stopped.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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