Drug interactions
Hydrochlorothiazide-losartan + Ofloxacin
Severity: Minor
Hydrochlorothiazide-losartan and Ofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin is partly renally secreted and thiazides might slightly reduce its clearance. The effect is small. Electrolyte disturbances from the diuretic could add to fluoroquinolone QT risk.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Ofloxacin belongs to Anti Bacterial.
Why it happens
Possible competition for renal tubular secretion; diuretic-induced hypokalemia may add to QT risk.
What to do
No dose adjustment is usually needed; correct potassium and magnesium abnormalities if present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Ofloxacin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ofloxacin is partly renally secreted and thiazides might slightly reduce its clearance. The effect is small. Electrolyte disturbances from the diuretic could add to fluoroquinolone QT risk.
How serious is the interaction between Hydrochlorothiazide-losartan and Ofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; correct potassium and magnesium abnormalities if present.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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