Drug interactions
Hydrochlorothiazide-losartan + Quinine
Severity: Moderate
Hydrochlorothiazide-losartan and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine is partly cleared renally and thiazides may slightly raise levels through tubular competition. More relevant, thiazide-induced hypokalemia or hypomagnesemia can increase quinine's QT-prolonging risk.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Possible tubular secretion competition; electrolyte depletion adds to QT prolongation.
What to do
Check and correct potassium and magnesium before and during quinine therapy, and obtain an ECG if other QT-prolonging drugs are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Quinine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine is partly cleared renally and thiazides may slightly raise levels through tubular competition. More relevant, thiazide-induced hypokalemia or hypomagnesemia can increase quinine's QT-prolonging risk.
How serious is the interaction between Hydrochlorothiazide-losartan and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before and during quinine therapy, and obtain an ECG if other QT-prolonging drugs are used.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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