Drug interactions
Hydrochlorothiazide-losartan + Salmeterol
Severity: Moderate
Hydrochlorothiazide-losartan and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol and hydrochlorothiazide can each lower serum potassium, and together hypokalemia may be more pronounced. This may raise the risk of arrhythmias, particularly in patients with cardiac disease or high-dose beta-agonist use. Losartan partly offsets potassium loss.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Salmeterol belongs to Respiratory.
Why it happens
Beta-2 agonist driven intracellular potassium shift adds to thiazide-induced renal potassium loss.
What to do
Monitor serum potassium, especially in patients with cardiac disease or at higher doses. Correct hypokalemia and consider potassium-sparing measures if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Salmeterol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salmeterol and hydrochlorothiazide can each lower serum potassium, and together hypokalemia may be more pronounced. This may raise the risk of arrhythmias, particularly in patients with cardiac disease or high-dose beta-agonist use. Losartan partly offsets potassium loss.
How serious is the interaction between Hydrochlorothiazide-losartan and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially in patients with cardiac disease or at higher doses. Correct hypokalemia and consider potassium-sparing measures if needed.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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