Drug interactions
Hydrochlorothiazide-losartan + Tadalafil
Severity: Moderate
Hydrochlorothiazide-losartan and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil has vasodilating properties and can add to the blood pressure lowering of losartan and hydrochlorothiazide. Symptomatic hypotension or dizziness may occur, especially at treatment initiation or in volume depleted patients.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
PDE5 inhibition causes vasodilation, adding to the antihypertensive effects of the ARB and diuretic.
What to do
Start tadalafil at a low dose and monitor blood pressure. Counsel patients about orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Tadalafil?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil has vasodilating properties and can add to the blood pressure lowering of losartan and hydrochlorothiazide. Symptomatic hypotension or dizziness may occur, especially at treatment initiation or in volume depleted patients.
How serious is the interaction between Hydrochlorothiazide-losartan and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start tadalafil at a low dose and monitor blood pressure. Counsel patients about orthostatic symptoms.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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