Drug interactions
Hydrochlorothiazide-losartan + Tretinoin
Severity: Minor
Hydrochlorothiazide-losartan and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is photosensitizing, and tretinoin, especially topical, increases skin sensitivity to sunlight. Combined use may increase sunburn or phototoxic reactions, but the effect is usually limited.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Tretinoin belongs to Dermatology.
Why it happens
Additive photosensitizing effects on the skin.
What to do
Advise sun protection with sunscreen and protective clothing, and review the skin if irritation or burns develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Tretinoin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide is photosensitizing, and tretinoin, especially topical, increases skin sensitivity to sunlight. Combined use may increase sunburn or phototoxic reactions, but the effect is usually limited.
How serious is the interaction between Hydrochlorothiazide-losartan and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise sun protection with sunscreen and protective clothing, and review the skin if irritation or burns develop.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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