Drug interactions
Hydrochlorothiazide-losartan + Valsartan
Severity: Major
Hydrochlorothiazide-losartan and Valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two angiotensin receptor blockers gives no added benefit and increases the risk of hypotension, hyperkalemia and renal impairment. Both are already present in combination with hydrochlorothiazide, adding to the burden of electrolyte disturbance.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Duplicate angiotensin II type 1 receptor blockade produces additive hemodynamic and potassium-retaining effects.
What to do
Avoid concurrent use of two ARBs and choose a single agent. If it has occurred, monitor potassium, creatinine and blood pressure and stop one drug.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Valsartan?
MediHelp rates the interaction as major. Hydrochlorothiazide-losartan and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two angiotensin receptor blockers gives no added benefit and increases the risk of hypotension, hyperkalemia and renal impairment. Both are already present in combination with hydrochlorothiazide, adding to the burden of electrolyte disturbance.
How serious is the interaction between Hydrochlorothiazide-losartan and Valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two ARBs and choose a single agent. If it has occurred, monitor potassium, creatinine and blood pressure and stop one drug.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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