Drug interactions
Hydrochlorothiazide-olmesartan + Labetalol
Severity: Moderate
Hydrochlorothiazide-olmesartan and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol adds to the blood pressure lowering of olmesartan and hydrochlorothiazide, which is often intended but can cause excessive hypotension or dizziness. This is a common, usually manageable combination.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through combined alpha/beta-adrenergic blockade, angiotensin receptor blockade and diuresis.
What to do
Monitor blood pressure and heart rate, particularly at initiation or dose changes, and adjust doses as needed. Counsel patients about orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Labetalol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol adds to the blood pressure lowering of olmesartan and hydrochlorothiazide, which is often intended but can cause excessive hypotension or dizziness. This is a common, usually manageable combination.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, particularly at initiation or dose changes, and adjust doses as needed. Counsel patients about orthostatic symptoms.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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