Drug interactions
Hydrochlorothiazide-olmesartan + Magnesium oxide
Severity: Minor
Hydrochlorothiazide-olmesartan and Magnesium oxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics increase urinary magnesium excretion, which can lower serum magnesium over time. Magnesium oxide supplementation may offset this loss, so the interaction is generally not harmful.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Magnesium oxide belongs to Gastrointestinal Tract.
Why it happens
Hydrochlorothiazide increases renal magnesium excretion, counteracting supplement exposure.
What to do
No dose change is usually needed; monitor serum magnesium in long-term thiazide users and adjust supplementation as required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Magnesium oxide?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics increase urinary magnesium excretion, which can lower serum magnesium over time. Magnesium oxide supplementation may offset this loss, so the interaction is generally not harmful.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Magnesium oxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor serum magnesium in long-term thiazide users and adjust supplementation as required.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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