Drug interactions
Hydrochlorothiazide-olmesartan + Metoprolol
Severity: Moderate
Hydrochlorothiazide-olmesartan and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoprolol adds to the blood pressure lowering of olmesartan and hydrochlorothiazide, which is often therapeutic but may cause hypotension or bradycardia. Thiazides and beta-blockers may also worsen glucose and lipid parameters.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Metoprolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through beta-adrenergic blockade, angiotensin receptor blockade and diuresis.
What to do
Monitor blood pressure and heart rate when starting or adjusting doses. Monitor glucose in diabetic patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-olmesartan and Metoprolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Metoprolol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoprolol adds to the blood pressure lowering of olmesartan and hydrochlorothiazide, which is often therapeutic but may cause hypotension or bradycardia. Thiazides and beta-blockers may also worsen glucose and lipid parameters.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting doses. Monitor glucose in diabetic patients.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
