Drug interactions
Hydrochlorothiazide-olmesartan + Saxagliptin
Severity: Minor
Hydrochlorothiazide-olmesartan and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and may modestly offset the glucose-lowering effect of DPP-4 inhibitors. The effect is usually small at the low hydrochlorothiazide doses found in combination products.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Saxagliptin belongs to Endocrine.
Why it happens
Thiazides cause hypokalemia and reduce insulin secretion and peripheral insulin sensitivity, which opposes antidiabetic action (pharmacodynamic antagonism).
What to do
Monitor blood glucose and HbA1c when starting or changing the thiazide combination, and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Saxagliptin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose and may modestly offset the glucose-lowering effect of DPP-4 inhibitors. The effect is usually small at the low hydrochlorothiazide doses found in combination products.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when starting or changing the thiazide combination, and adjust antidiabetic therapy if control worsens.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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