Drug interactions
Hydrochlorothiazide-olmesartan + Torsemide
Severity: Moderate
Hydrochlorothiazide-olmesartan and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a loop diuretic with a thiazide gives synergistic diuresis, increasing the risk of volume depletion, hypotension, hypokalemia, hyponatremia and renal impairment. Olmesartan may partly offset potassium loss but adds to the risk of renal hypoperfusion.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
Why it happens
Sequential nephron blockade with additive diuretic effect and electrolyte loss, combined with ARB-related renal hemodynamic changes.
What to do
Monitor electrolytes, creatinine, weight and blood pressure, particularly in the first weeks. Reduce diuretic doses if volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Torsemide
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Torsemide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a loop diuretic with a thiazide gives synergistic diuresis, increasing the risk of volume depletion, hypotension, hypokalemia, hyponatremia and renal impairment. Olmesartan may partly offset potassium loss but adds to the risk of renal hypoperfusion.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, creatinine, weight and blood pressure, particularly in the first weeks. Reduce diuretic doses if volume depletion occurs.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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