Drug interactions
Hydrochlorothiazide-olmesartan + Trientine
Severity: Minor
Hydrochlorothiazide-olmesartan and Trientine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics increase urinary excretion of copper-chelating agents only in theory, and the clinical effect on trientine levels is not well documented. Diuretic-induced volume or electrolyte changes may matter more than any kinetic effect.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Trientine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Trientine belongs to Miscellaneous.
Why it happens
Mechanism not well established; possible altered renal clearance of trientine.
What to do
Monitor copper control (urinary copper, free serum copper) and electrolytes when therapy is started or changed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Trientine
- Calcium + Trientine Moderate
- Carbonyl iron + Trientine Moderate
- Copper + Trientine Moderate
- Ferrous fumarate + Trientine Moderate
- Ferrous gluconate + Trientine Moderate
- Ferrous sulfate + Trientine Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Trientine?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Trientine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics increase urinary excretion of copper-chelating agents only in theory, and the clinical effect on trientine levels is not well documented. Diuretic-induced volume or electrolyte changes may matter more than any kinetic effect.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Trientine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor copper control (urinary copper, free serum copper) and electrolytes when therapy is started or changed.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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