Drug interactions
Hydrochlorothiazide-olmesartan + Trofinetide
Severity: Moderate
Hydrochlorothiazide-olmesartan and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide may inhibit OATP1B1 and OATP1B3 and could raise olmesartan concentrations. This may enhance hypotension or hyperkalemia and renal effects.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Trofinetide belongs to Central Nervous System.
Why it happens
Inhibition of OATP1B1/1B3 hepatic uptake may reduce olmesartan clearance.
What to do
Monitor blood pressure, potassium and renal function. Reduce olmesartan dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Trofinetide
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Trofinetide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide may inhibit OATP1B1 and OATP1B3 and could raise olmesartan concentrations. This may enhance hypotension or hyperkalemia and renal effects.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and renal function. Reduce olmesartan dose if hypotension occurs.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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