Drug interactions
Hydrochlorothiazide-telmisartan + Isoproterenol
Severity: Moderate
Hydrochlorothiazide-telmisartan and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoproterenol and hydrochlorothiazide can each lower serum potassium. Together they may cause hypokalemia, which increases the risk of arrhythmias, particularly in patients with cardiac disease.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Isoproterenol belongs to Respiratory.
Why it happens
Beta-adrenergic stimulation shifts potassium into cells while the thiazide increases renal potassium excretion, causing additive hypokalemia.
What to do
Check serum potassium and ECG changes during isoproterenol use in patients on the thiazide. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Isoproterenol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoproterenol and hydrochlorothiazide can each lower serum potassium. Together they may cause hypokalemia, which increases the risk of arrhythmias, particularly in patients with cardiac disease.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and ECG changes during isoproterenol use in patients on the thiazide. Replace potassium as needed.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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