Drug interactions
Hydrochlorothiazide-telmisartan + Levodopa
Severity: Moderate
Hydrochlorothiazide-telmisartan and Levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, and combining it with antihypertensives such as telmisartan and hydrochlorothiazide may amplify blood pressure lowering. This can lead to dizziness and falls, especially at treatment initiation.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Levodopa belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from dopamine-mediated vasodilation and autonomic effects of levodopa combined with antihypertensive therapy.
What to do
Check supine and standing blood pressure when starting or increasing levodopa and reduce the antihypertensive dose if symptomatic hypotension occurs. Advise patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Levodopa?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, and combining it with antihypertensives such as telmisartan and hydrochlorothiazide may amplify blood pressure lowering. This can lead to dizziness and falls, especially at treatment initiation.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check supine and standing blood pressure when starting or increasing levodopa and reduce the antihypertensive dose if symptomatic hypotension occurs. Advise patients to rise slowly.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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