Drug interactions
Hydrochlorothiazide-telmisartan + Pivmecillinam
Severity: Minor
Hydrochlorothiazide-telmisartan and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pivmecillinam is converted to mecillinam, a penicillin that is eliminated by renal tubular secretion. Diuretics such as hydrochlorothiazide may compete for this secretion, but the clinical effect is small and there is no well-documented harm. Hydrochlorothiazide can also cause volume depletion, which affects renal clearance modestly.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Pivmecillinam belongs to Anti Bacterial.
Why it happens
Possible competition for renal tubular secretion between thiazide and beta-lactam, which is not well established clinically for this pair.
What to do
No dose change is usually needed; monitor renal function and hydration status during the antibiotic course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Pivmecillinam?
MediHelp rates the interaction as minor. Hydrochlorothiazide-telmisartan and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pivmecillinam is converted to mecillinam, a penicillin that is eliminated by renal tubular secretion. Diuretics such as hydrochlorothiazide may compete for this secretion, but the clinical effect is small and there is no well-documented harm. Hydrochlorothiazide can also cause volume depletion, which affects renal clearance modestly.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor renal function and hydration status during the antibiotic course.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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