Drug interactions
Hydrochlorothiazide-telmisartan + Prednisone
Severity: Moderate
Hydrochlorothiazide-telmisartan and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote potassium loss, so combining them increases the risk of hypokalemia, which can cause weakness and arrhythmias. Telmisartan raises potassium and may partly offset the effect.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Prednisone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from thiazide diuresis and corticosteroid mineralocorticoid activity.
What to do
Monitor serum potassium and magnesium, especially at the start of therapy and with prolonged steroid use. Supplement potassium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Prednisone?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs promote potassium loss, so combining them increases the risk of hypokalemia, which can cause weakness and arrhythmias. Telmisartan raises potassium and may partly offset the effect.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, especially at the start of therapy and with prolonged steroid use. Supplement potassium if needed.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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