Drug interactions
Hydrochlorothiazide-telmisartan + Probenecid
Severity: Moderate
Hydrochlorothiazide-telmisartan and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces the uricosuric effectiveness when thiazides raise serum uric acid, and thiazides can antagonize its urate-lowering effect. Probenecid may also raise hydrochlorothiazide levels by reducing its tubular secretion.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Competition for organic anion tubular secretion and thiazide-induced hyperuricemia opposing uricosuric action.
What to do
Monitor serum uric acid and gout control, and blood pressure. Adjust probenecid dose or consider a non-thiazide antihypertensive if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Probenecid?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces the uricosuric effectiveness when thiazides raise serum uric acid, and thiazides can antagonize its urate-lowering effect. Probenecid may also raise hydrochlorothiazide levels by reducing its tubular secretion.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout control, and blood pressure. Adjust probenecid dose or consider a non-thiazide antihypertensive if control is lost.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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