Drug interactions
Hydrochlorothiazide-telmisartan + Treprostinil
Severity: Moderate
Hydrochlorothiazide-telmisartan and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator, and combining it with telmisartan and hydrochlorothiazide may produce additive blood pressure reduction and symptomatic hypotension. Treprostinil also inhibits platelet function, which is unrelated to this pair.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilatory and antihypertensive pharmacodynamic effects.
What to do
Monitor blood pressure when starting or adjusting treprostinil and reduce antihypertensive doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Treprostinil?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent vasodilator, and combining it with telmisartan and hydrochlorothiazide may produce additive blood pressure reduction and symptomatic hypotension. Treprostinil also inhibits platelet function, which is unrelated to this pair.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or adjusting treprostinil and reduce antihypertensive doses if symptomatic hypotension occurs.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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