Drug interactions
Hydrochlorothiazide-valsartan + Isoproterenol
Severity: Moderate
Hydrochlorothiazide-valsartan and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoproterenol, a beta-agonist, shifts potassium into cells, and with thiazide-induced potassium loss this can lower serum potassium further. Hypokalemia increases the risk of arrhythmia, especially in patients with heart disease.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Isoproterenol belongs to Respiratory.
Why it happens
Additive hypokalemia from beta-2 stimulated intracellular potassium shift and thiazide renal potassium wasting.
What to do
Monitor serum potassium and ECG in patients receiving isoproterenol, and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Isoproterenol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoproterenol, a beta-agonist, shifts potassium into cells, and with thiazide-induced potassium loss this can lower serum potassium further. Hypokalemia increases the risk of arrhythmia, especially in patients with heart disease.
How serious is the interaction between Hydrochlorothiazide-valsartan and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG in patients receiving isoproterenol, and replace potassium as needed.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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