Drug interactions
Hydrochlorothiazide-valsartan + Leniolisib
Severity: Moderate
Hydrochlorothiazide-valsartan and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits OATP1B1 and OATP1B3, the hepatic uptake transporters for valsartan. Valsartan exposure may increase, with more hypotension and effects on renal function and potassium.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Leniolisib belongs to Miscellaneous.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake of valsartan.
What to do
Monitor blood pressure, renal function and potassium after starting leniolisib. Lower the valsartan dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Leniolisib?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits OATP1B1 and OATP1B3, the hepatic uptake transporters for valsartan. Valsartan exposure may increase, with more hypotension and effects on renal function and potassium.
How serious is the interaction between Hydrochlorothiazide-valsartan and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium after starting leniolisib. Lower the valsartan dose if hypotension develops.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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