Drug interactions
Hydrochlorothiazide-valsartan + Methoxsalen
Severity: Moderate
Hydrochlorothiazide-valsartan and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is a known photosensitizer, and methoxsalen is a potent photosensitizing psoralen used with UVA exposure. Concurrent use may increase the risk of exaggerated phototoxic skin reactions such as burns.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Methoxsalen belongs to Anti Fungals.
Why it happens
Additive photosensitizing effects of both drugs.
What to do
Counsel on strict sun protection and avoidance of unplanned UV exposure. Adjust the phototherapy dose and inspect the skin for erythema or burns during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Methoxsalen?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide is a known photosensitizer, and methoxsalen is a potent photosensitizing psoralen used with UVA exposure. Concurrent use may increase the risk of exaggerated phototoxic skin reactions such as burns.
How serious is the interaction between Hydrochlorothiazide-valsartan and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on strict sun protection and avoidance of unplanned UV exposure. Adjust the phototherapy dose and inspect the skin for erythema or burns during treatment.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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